Neutrophil Adhesion Migration and Phagocytosis

A neutrophil travels along the capillary endothelial layer. Endothelial cells are triggered to express selectins on their surface for neutrophil integrin-mediated adherence. Transendothelial migration allows the neutrophil to traverse the blood endothelial layer. Squeezing into the extra-capillary space where migration towards a chemotactic gradient (chemotaxis) helps it to locate the pathogen. Subsequent phagocytosis ensues.