Renal Failure from Vitamin C after Transplantation

A 31-year-old woman with bilateral nephrectomy due to bleeding angiomyolipomas from tuberous sclerosis received a kidney transplant with good early graft function. Irreversible, oliguric renal allograft failure soon developed from widespread deposition of calcium oxalate crystals, involving 30% of tubules (Panels A and B, hematoxylin and eosin). The patient ..........

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