Renal Amyloid by Electron microscopy

Electron microscopy shows massive expansion of the mesangium by fibrillar material with randomly oriented thin fibrils with a diameter of 10 to 12 nm, often extending to basement membranes as in this case (transmission electron microscopy; original magnification x8,000).

By electron microscopy, amyloid appears as randomly oriented thin fibrils, 10 to 12 nm in diameter, with a loose, flocculent background (transmission electron microscopy; original magnification x51,250).

Amyloid infiltration through the basement membrane with resulting feathery spikes with basement membrane material and delicate amyloid fibrils are shown in this case (transmission electron microscopy; original magnification x20,250).